2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0612ES
    (S)-Lercanidipine-d3 hydrochloride 1217740-02-7 98%
    (S)-Lercanidipine-d3 hydrochloride is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent.
    (S)-Lercanidipine-d3 hydrochloride
  • HY-B0615AS
    Moricizine-d8(Hydrochloride) 2300178-76-9 98%
    Moricizine-d8 (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period.
    Moricizine-d8(Hydrochloride)
  • HY-B0636S1
    Triamcinolone acetonide-13C3 1264131-86-3 98%
    Triamcinolone acetonide-13C3 is the 13C-labeled Triamcinolone acetonide (HY-B0636). Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis.
    Triamcinolone acetonide-13C3
  • HY-B0637S1
    Bezafibrate-d4 1189452-53-6 98%
    Bezafibrate-d4 is deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
    Bezafibrate-d4
  • HY-B0653AS
    Levobupivacaine-d9 hydrochloride 98%
    Levobupivacaine-d9 ((S)-(–)-Bupivacaie-d9) hydrochloride is deuterium labeled Levobupivacaine hydrochloride (HY-B0653A). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer.
    Levobupivacaine-d9 hydrochloride
  • HY-B0686BR
    Eptifibatide acetate (Standard) 881997-86-0
    Eptifibatide (acetate) (Standard) is the analytical standard of Eptifibatide (acetate). This product is intended for research and analytical applications. Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.
    Eptifibatide acetate (Standard)
  • HY-B0757AR
    (±)-α-Tocopherol nicotinate (Standard) 51898-34-1
    (±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
    (±)-α-Tocopherol nicotinate (Standard)
  • HY-B1014S1
    Acenocoumarol-d4 2937878-24-3 98%
    Acenocoumarol-d4 is deuterium labeled Acenocoumarol.
    Acenocoumarol-d4
  • HY-B1334AS
    Perhexiline-d11 maleate 98%
    Perhexiline-d11 (maleate) is the deuterium labeled Perhexiline maleate. Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.
    Perhexiline-d11 maleate
  • HY-B1438S1
    Canrenone-d4 98%
    Canrenone-d4 is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
    Canrenone-d4
  • HY-B1448AS
    (Rac)-Benidipine-d7 98%
    (Rac)-Benidipine-d7 is the deuterium labeled Benidipine. Benidipine is a potent and orally active calcium channel antagonist. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats.
    (Rac)-Benidipine-d7
  • HY-B1486AS
    Oxprenolol-d7 1189805-10-4 98%
    Oxprenolol-d7 is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
    Oxprenolol-d7
  • HY-B1538AR
    Bamethan hemisulfate (Standard) 5716-20-1
    Bamethan (hemisulfate) (Standard) is the analytical standard of Bamethan (hemisulfate). This product is intended for research and analytical applications. Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels.
    Bamethan hemisulfate (Standard)
  • HY-B1654AR
    Flavin adenine dinucleotide disodium salt (Standard) 84366-81-4
    Flavin adenine dinucleotide (disodium salt) (Standard) is the analytical standard of Flavin adenine dinucleotide (disodium salt). This product is intended for research and analytical applications. Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide disodium salt (Standard)
  • HY-B1659S1
    Glycerol-13C 98292-00-3 98%
    Glycerol-13C is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
    Glycerol-13C
  • HY-B1659S3
    Glycerol-d1 98%
    Glycerol-d is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
    Glycerol-d1
  • HY-B1836AR
    Meldonium dihydrate (Standard) 86426-17-7
    Meldonium (dihydrate) (Standard) is the analytical standard of Meldonium (dihydrate). This product is intended for research and analytical applications. Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor.
    Meldonium dihydrate (Standard)
  • HY-E70541A
    Bovine Factor IX 9001-28-9 98%
    Bovine Factor IX is prepared from freshly collected bovine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa.
    Bovine Factor IX
  • HY-E70541B
    Canine Factor IX 9001-28-9 98%
    Canine Factor IX is prepared from freshly collected canine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa.
    Canine Factor IX
  • HY-E70544A
    Bovine Factor X 9001-29-0 98%
    Bovine Factor X is prepared from freshly collected bovine plasma and, after activation, can convert prothrombin to thrombin.
    Bovine Factor X
Cat. No. Product Name / Synonyms Application Reactivity